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LSD is the most common hallucinogen and is one of the most potent mood-changing chemicals. It is manufactured from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains.

Lysergic acid diethylamide (abbreviated as LSD or LSD-25; and also known as Lysergide, Acid or Lucy) is a semisynthetic psychedelic substance of the lysergamide family.

LSD was initially synthesized by Albert Hofmann in 1938 from ergotamine, a chemical derived from ergot (a grain fungus that typically grows on rye). The short form “LSD” comes from its early code name LSD-25 which is an abbreviation for the German spelling “Lysergsäure-diethylamid” followed by a sequential number.

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. Its potency may last for years if it is stored away from light and moisture at cold temperatures around 0°C or below, but will slowly degrade at normal room temperature (25°C). In one study, there was a 10% loss of potency after LSD was kept at room temperature for one month. However, there are also many anecdotal reports from users who have successfully stored LSD at room temperature for years which contradict the findings of this study.

What are its short-term effects?

The effects of LSD are unpredictable, and occur based on factors such as on the amount taken, the user’s personality, mood, expectations and the surroundings in which the drug is used. The physical effects include dilated pupils, higher body temperature, increased heart rate and blood pressure, sweating, loss of appetite, sleeplessness, dry mouth and tremors. Sensations and feelings change much more dramatically than the physical signs.  The user may feel several different emotions at once or swing rapidly from one emotion to another.  If taken in a large enough dose, the drug produces delusions and visual hallucinations.  The user’s sense of time and self changes.  Sensations may seem to “cross over,” giving the user the feeling of hearing colors and seeing sounds. These changes can be frightening and can cause panic.

What are its long-term effects?

Some LSD users experience flashbacks, recurrence of certain aspects of a person’s experience even if the user doesn’t take the drug again.  A flashback occurs suddenly, often without warning, and may occur within a few days or more than a year after LSD use.  Most users of LSD voluntarily decrease or stop its use over time. LSD is not considered to be an addicting drug because it does not produce compulsive drug-seeking behavior like cocaine, amphetamines, heroin, alcohol, or nicotine.