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The JWH-018 is a synthetic cannabinoid, meaning it is made of lab-created chemicals. It has been on the market since 2007 and has been sold legally in some countries until it was classified as a controlled drug in 2011.

The DEA classifies JWH-018 as a schedule I substance, which means that it is illegal to use, possess, distribute or manufacture this drug in the United States.

The chemical structure of JWH-018 was created by John W. Huffman, an organic chemist at Clemson University. He created the molecule to answer the need for inexpensive research tools that could be used to study cannabinoid receptors in brain tissue samples.